Heartburn drugs known as proton pump inhibitors (PPIs) are among the most commonly used drugs in the world. About 15 million Americans use PPIs, either in prescription or over-the-counter form. Brand names include Prilosec, Prevacid and Nexium.
The drugs have long been touted as a safe way to relieve heartburn, indigestion and acid reflux. They work by inhibiting the production of acid in your stomach, which helps to relieve symptoms but appears to have a number of unintended consequences as well, including for your kidneys.
PPIs have previously been linked to a kidney disorder called acute interstitial nephritis. Now researchers have linked them to the risk of chronic kidney disease, prompting experts to call for more caution in their use.
Heartburn Drugs May Increase Your Risk of Kidney Disease
Researchers from the Johns Hopkins Bloomberg School of Health analyzed two sets of data representing more than 250,000 people.1
In the first set, the 10-year absolute risk of developing chronic kidney disease was 11.8 percent among those taking PPIs compared to 8.5 percent among those not taking the drugs.
The second analysis found the 10-year absolute risk of chronic kidney disease among those taking PPIs was 15.6 percent compared to 13.9 percent among non-users.2
The study left some unanswered questions, like how long those who developed kidney disease had been taking PPIs. It’s also not known how the drugs may be harming the kidneys.
Many of those taking PPIs had other risk factors for kidney disease as well, including being more likely to use blood pressure medication (high blood pressure is linked to an increased risk of kidney disease).
However, even though the analysis couldn’t prove that PPIs were directly responsible for the increased risk of kidney disease, the finding warrants caution in the drugs’ use, especially given their prevalence.
Adam Schoenfeld, an internal medicine resident at the University of California, San Francisco, said in an accompanying editorial, “mounting evidence demonstrates that PPIs are associated with a number of adverse effects and are overprescribed.”3 He continued in NPR:
“I think it’s a pretty big concern … When they first came out they weren’t associated with side effects, or we didn’t think they were … So we put [people] on this medication thinking: ‘It’s a quick fix and they’re very safe.’ But in actuality they’re associated with a range of side effects.”
PPIs Are Also Linked to Heart Risks
If you take PPIs, you should know that not only might your kidneys be at risk, but your heart may suffer as well.
After reviewing the medical records of nearly 3 million people, researchers from Stanford University in California found people with gastroesophageal reflux disease (GERD) who took PPIs had a 16 percent risk of heart attack.4
A two-fold increased risk of cardiovascular mortality was also noted in PPI users.5 Such risks make sense when you consider that PPIs are known to reduce nitric oxide (NO) in your blood vessel walls.
NO has the effect of relaxing your blood vessels, so by reducing the amount of NO in your blood vessel walls, PPIs may raise your risk of a heart attack.
PPIs May Raise Your Risk of Fractures
In 2010, the U.S. Food and Drug Administration (FDA) mandated a new fracture risk warning be added to the labels of both prescription and OTC PPIs.
The safety announcement was based on a review of several epidemiological studies, which found the drugs were associated with an increased risk of factures of the hip, wrist and spine.6
The greatest risk of increased facture risk was found in people who had taken high doses of the drugs (available only in prescription form) or had taken the prescription drugs for at least one year.
Because of this, in 2011 the FDA recalled the safety warning for OTC PPIs, stating that “an osteoporosis and fracture warning on the over-the-counter (OTC) proton pump inhibitor (PPI) medication “Drug Facts” label is not indicated at this time.”7
Their reasoning was that OTC PPIs “are marketed at low doses and are only intended for a 14-day course of treatment up to three times per year.” Since OTC heartburn drugs are only supposed to be used for short courses of treatment, they believed the fracture risk was low.
In reality, however, many people use OTC heartburn meds for much longer than two weeks at a time, and therefore might be exposed to them long-term. Some people may also take higher doses than are recommended. Even the FDA acknowledged this, stating:
“… [C]onsumers, either on their own, or based on a healthcare professional’s recommendation, may take these products for periods of time that exceed the directions on the OTC label.”
Unfortunately, instead of letting consumers know about the fracture risk (so they could make an informed decision about using the drugs), the FDA left it up to health care professionals to be aware of the fracture risk in patients taking OTC PPIs at high doses or for extended periods.
If there’s no communication between the two parties, the consumer will be left at risk.
PPIs May Rob Your Body of Important Nutrients, Increase Your Risk of Serious Infections
If you suffer from acid reflux, suppressing your stomach acid may seem like a very good idea. Be aware, however, that doing so comes with significant risks. Stomach acid is important for your body to absorb vitamin B12, for instance.
The acid separates the B12 from the protein it’s attached to, which is essential for it to be absorbed by your body. People taking PPIs for more than two years had a 65 percent increased risk of vitamin B12 deficiency.8 This, in turn, can lead to a number of troublesome ailments, including:
- Nerve damage
- Psychiatric problems
Your magnesium levels are also at risk. In 2011, the FDA warned that PPIs may cause low magnesium levels if taken for longer than one year. Even taking a magnesium supplement was not enough to sufficiently increase levels among about one-quarter of those taking PPIs.9
Early signs of magnesium deficiency include loss of appetite, headache, nausea, fatigue, and weakness. Ongoing magnesium deficiency can lead to muscle cramps, seizures, abnormal heart rhythms, personality changes and more.
Further, PPIs may increase your risk of Clostridium difficile-associated diarrhea, a potentially life-threatening infection, by 65 percent.10 The risk of hospital-acquired pneumonia may also increase with PPI use, an important consideration since PPIs are commonly given to hospital patients.
One study using a microsimulation model found that this practice needs serious review, as new initiation of PPI therapy led to an increase in hospital mortality in about 90 percent of patients.11
Reducing stomach acid also diminishes your primary defense mechanism against food-borne pathogens, thereby potentially increasing your risk of food poisoning.
Heartburn Drugs Only Treat the Symptoms, Not the Cause
In most cases, acid reflux is not due to having too much acid in your stomach; rather, it’s a condition related more commonly to hiatal hernia — a condition in which the acid comes out of your stomach, which is where it’s designed to be confined to. After food passes through your esophagus into your stomach, a muscular valve called the lower esophageal sphincter (LES) closes, preventing food or acid from moving back up.
Gastroesophageal reflux occurs when the LES relaxes inappropriately, allowing acid from your stomach to flow (reflux) backward into your esophagus.
In the early ‘80s, Dr. Barry Marshall, an Australian physician, discovered that an organism called helicobacter pylori(initially called campylobacter) causes a chronic low-level inflammation of your stomach lining, which is largely responsible for producing many of the symptoms of acid reflux.
One of the explanations for why suppressing stomach acid is so ineffective — and there are over 16,000 articles in the medical literature attesting to this — is that when you decrease the amount of acid in your stomach, you suppress your body’s ability to kill the helicobacter bacteria.
So suppressing stomach acid production tends to just worsen and perpetuate the condition. If you’re taking a PPI drug to treat your heartburn, understand that you’re treating a symptom only; you are in no way addressing the underlying cause. And, by doing so, you’re exposing yourself to other potentially more dangerous health problems, courtesy of the drug itself.
That being said, please don’t try to quit PPIs cold turkey, as this can lead to a relapse and severe pain. To minimize this risk, you can gradually decrease the dose you’re taking, and once you get down to the lowest dose of the PPI, you can start substituting with an OTC H2 blocker like Tagamet, Cimetidine, Zantac, or Ranitidine.
Then gradually wean off the H2 blocker over the next several weeks. While weaning yourself off these drugs, start implementing the lifestyle modifications discussed below to help eliminate your heartburn once and for all.
Heartburn May Be Due to Too Little Stomach Acid
If you struggle from heartburn, it may be because you have too little stomach acid. One simple strategy to address this deficiency is to swap out processed table salt for an unprocessed version like Himalayan salt. By consuming enough of the raw material, you will encourage your body to make sufficient amounts of hydrochloric acid (stomach acid) naturally.
Sauerkraut or cabbage juice is among the strongest stimulants for your body to produce stomach acid as well. Another benefit is that it can provide you with valuable bacteria to help balance and nourish your gut. Having a few teaspoons of cabbage juice before eating, or better yet, fermented cabbage juice from sauerkraut, will do wonders to improve your digestion. Fresh raw cabbage juice can also be very useful to heal resistant ulcers.12
Another option is to take a betaine hydrochloric supplement, which is available in health food stores without prescription. You’ll want to take as many as you need to get the slightest burning sensation and then decrease by one capsule. This will help your body to better digest your food and will also help kill the helicobacter and normalize your symptoms.
Now, while hiatal hernia and H.pylori infection are unrelated, many who have a hiatal hernia also have H. pylori and associated symptoms.13 If you have a hiatal hernia, physical therapy on the area may work as well, and many chiropractors are skilled in this adjustment.
Natural Treatment for Heartburn
Ultimately, the answer to heartburn and acid indigestion is to restore your natural gastric balance and function and to do that, you need to address your gut health. The most important step is to eliminate processed foods and sugars as they are a surefire way to exacerbate acid reflux.
They also alter your gut microbiome and promote the growth of pathogenic microbes. So be sure to eat lots of fresh vegetables and other unprocessed organic foods. Food allergies can also be a contributing factor to acid reflux, so eliminate items such as caffeine, alcohol, and nicotine.
Reseeding your gut with beneficial bacteria, either from traditionally fermented foods or a high-quality probiotic supplement is also important, as this will not only help balance your bowel flora, it can also help eliminate helicobacter bacteria naturally. Probiotics and fermented foods, especially fermented vegetables, also aid in proper digestion and assimilation of your food. Other helpful strategies to get your heartburn under control include the following suggestions.14,15,16
|Raw, unfiltered apple cider vinegar||You can help improve the acid content of your stomach by taking one tablespoon of raw unfiltered apple cider vinegar in a large glass of water.|
|Baking soda||One-half to one full teaspoon of baking soda (sodium bicarbonate) in an eight-ounce glass of water may ease the burn of acid reflux as it helps neutralize stomach acid. I would not recommend this as a regular solution but it can sure help in an emergency when you are in excruciating pain.|
|Aloe juice||The juice of the aloe plant naturally helps reduce inflammation, which may ease symptoms of acid reflux. Drink about 1/2 cup of aloe vera juice before meals. If you want to avoid its laxative effect, look for a brand that has removed the laxative component.|
|Ginger root||Ginger has been found to have a gastroprotective effect by blocking acid and suppressing helicobacter pylori. According to a 2007 study, it’s also far superior to lansoprazole for preventing the formation of ulcers, exhibiting six- to eight-fold greater potency over the drug.17
This is perhaps not all that surprising, considering the fact that ginger root has been traditionally used against gastric disturbances since ancient times. Add two or three slices of fresh ginger root to two cups of hot water. Let steep for about half an hour. Drink about 20 minutes or so before your meal.
|Vitamin D||Vitamin D is important for addressing any infectious component. Once your vitamin D levels are optimized, you’re also going to optimize your production of about 200 antimicrobial peptides that will help your body eradicate any infection that shouldn’t be there.
As I’ve discussed in many previous articles, you can increase your vitamin D levels through sensible sun exposure, or through the use of a tanning bed. If neither of those are available, you can take an oral vitamin D3 supplement; just remember to also increase your vitamin K2 intake.
|Astaxanthin||This exceptionally potent antioxidant was found to reduce symptoms of acid reflux in patients when compared to a placebo, particularly in those with pronounced helicobacter pylori infection.18 Best results were obtained at a daily dose of 40 mg.|
|Slippery elm||Slippery elm coats and soothes your mouth, throat, stomach, and intestines, and contains antioxidants that may help address inflammatory bowel conditions. It also stimulates nerve endings in your gastrointestinal tract. This helps increase mucus secretion, which protects your gastrointestinal tract against ulcers and excess acidity.
The University of Maryland Medical Center makes the following adult dosing recommendations:19
|Glutamine||Research published in 2009 found that gastrointestinal damage caused by H. pylori can be addressed with the amino acid glutamine, found in many foods, including beef, chicken, fish, eggs, dairy products, and some fruits and vegetables.20 L-glutamine, the biologically active isomer of glutamine, is also widely available as a supplement.|
|Folate or folic acid (vitamin B9) and other B vitamins||As reported by clinical nutritionist Byron Richards, research suggests B vitamins can reduce your risk for acid reflux.21 Higher folic acid intake was found to reduce acid reflux by approximately 40 percent.
Low vitamin B2 and B6 levels were also linked to an increased risk for acid reflux. The best way to raise your folate levels is by eating folate-rich whole foods, such a sliver, asparagus, spinach, okra, and beans.
|Melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine, and betaine||A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine, and betaine, was found to be superior to the drug omeprazole in the treatment of GERD.22
Part of the success is thought to be due to melatonin’s inhibitory activity on nitric oxide biosynthesis, which plays an important role in transient LES relaxation, which, as I mentioned earlier, is part of the real underlying problem of GERD.
Impressively, 100 percent of patients receiving this supplement reported a complete regression of symptoms after 40 days of treatment, compared to just under 66 percent of those taking omeprazole. The authors concluded that “this formulation promotes regression of GERD symptoms with no significant side effects.”
A quick note from our founder-
Over the past year, my friend Dave at PaleoHacks has been working on a secret cookbook with world-renowned Le Cordon Bleu chef Peter Servold.
Well, today this new this new incredible Paleo Cookbook is finally available to be shipped right to your door for FREE
That's right -- as a special launch promotion, we're offering our brand new Paleo fat loss cookbook to you for free (Chef Pete lost 60 lbs using these recipes!) -- All you have to do is just cover a small shipping cost (international shipping is a bit more).
Get your FREE copy of Paleo Eats Here. (Grab this today, because we only ordered a small batch of these cookbooks for this freebie promotion, and they will sell out FAST!)
Help us create more awareness! Please SHARE this article...
I bet you can’t guess which muscle in your body is the #1 muscle that eliminates joint and back pain, anxiety and looking fat.
This “hidden survival muscle” in your body will boost your energy levels, immune system, sexual function, strength and athletic performance when unlocked.
If this “hidden” most powerful primal muscle is healthy, we are healthy.
d) Hip Flexors
Take the quiz above and see if you got the correct answer!
P.S. Make sure you check out the next page to get to know the 10 simple moves that will bring vitality back into your life!
To begin, I apologize for the dark nature of today's email.
However I promise what you'll discover today will be completely worth it.
Imagine a rotting corpse draped over your body from head to toe...
...suffocating tissue, restricting blood flow, damaging joints and infecting your healthy cells.
Shockingly, that nightmare is a reality for most:
64% of women and 74% of men carry too much body fat according to the National Institutes of Health.
It's choking their organs, assaulting their metabolism and sucking their energy dry.
But here's the worst part:
For most, this bodyfat has become "calorie-resistant":
It's completely unaffected by even the strictest diets... and most intense exercises.
This zombie fat is essentially... "dead tissue".
That's important for those who have 10, 25 or 50 or more pounds to lose...
AND for those who aren't technically overweight, but have what's called "pocket obesity"...
...unsightly patches of fat that cling to specific places, like:
just above your hips, lower belly, where your butt and legs meet... and even arms, neck and face.
However, there's good news:
Obesity researchers have now discovered a "metabolic jumper cable":
It jolts dead bodyfat back to life.
This allows your metabolism to burn it as calories and re-energize your entire body.
First though, here's the #1 reason why bodyfat becomes calorie-resistant:
It lacks blood flow. This has 3 effects:
- Not enough oxygen or nutrients reach fat cells, so they become unresponsive..
- Released fat can't be sent to other tissues to be burned, so fat cells suck it back in...
- 3) Metabolic hormones carrying the "burn calories" message don't reach the fat cell...
All this means one thing:
Your body can't transform into energy, the 135,000+ of calories the average person stores as fat!
You become a metabolic zombie: NO energy to think. NO energy to move. NO energy to motivate.
Update: calorie-resistant bodyfat can be now removed...
The discovery of this "metabolic jumper cable" can now reverse this process:
- It wakes up un-responsive bodyfat with a powerful calorie-burning hormonal jolt....
- It pops open fat cells, sucks out the fat, sending it off before its yanked back in...
- It shuttles fat to your brain, heart, lungs, kidneys - even your bones - to be burned as energy.
Not only do those layers of "zombie fat" start coming off, but your entire body just works better.
Plus, as your whole body burns more calories, those patches of pocket obesity whittle away.
This "metabolic jumper cable" isn't any exercise, machine or pill.
It's a little-known, calorie-burning hormone we all have... just waiting for the right spark to come alive.
It's not thyroid, leptin, ghrelin, insulin, adiponectin, HGH or any other "fat loss" hormone you may know.
And on this next page, you'll find out precisely how to unleash its calorie-burning power:
PS - Studies show that not only can healthy levels of this powerful calorie-burning hormone devour bodyfat and fortify soft muscle, but it can also reduce your risk of diabetes by 53.7%, a heart attack by 83.3% and stroke by 51.4%. Here's more of the scientific proof...
In April, 2009, researchers stunned the medical community when they reported chronic inflammation as the root cause of several major diseases.
See, every year 610,000 people in the U.S. die of heart disease. Cancer claims another 584,000...stroke 130,000...Alzheimer's disease nearly 85,000 — and the list goes on.
Truth is, we now know... chronic inflammation is responsible for 7 out of the top 10 leading causes of death in the United States! Hundreds of studies and scientific reviews prove it.
Fortunately, newer research shows you can prevent-even reverse-most major diseases by "turning off" inflammation. And in our new book, we show you how to do just that.
If you or a loved one is suffering from a debilitating condition-and you"re not sure what the culprit is-now's the time to find out...while you can still do something about it!
--> Grab your FREE copy of this groundbreaking soft cover book today (while supplies still last.)
If you haven't heard of Claude Davis yet do yourself a huge favor and watch this video. He's going to be the talk of 2016.
One of the smartest guys I ever had the pleasure of meeting, Claude set-up a unique system that changed his life forever.
I already tried it myself and let me tell... you I was completely blown away... His surprising tactics could make your life easier and give you the peace of mind you deserve.
Don't just take my word for it... watch his short video and decide for yourself.
Is Bread Really the Staff of Life… or the Stuff of Disease?
For most us, there are few foods more comforting than bread.
Fluffy biscuits, crusty baguettes, flaky croissants… even a simple slice of toast topped with melted butter can taste like heaven.
And that smell… few scents are quite as pleasant as fresh bread baking in the oven.
But there is a lot of confusion as to where bread fits into a healthy diet.
The Bible practically commands followers to eat it: “Give us this day our daily bread…” The government put it at the base of the food pyramid. And for centuries, it has been called “the staff of life.”
Of course, there are some who disagree…
Well-known cardiologist, Dr. William Davis, calls wheat “the perfect chronic poison.”
And for a poison, we sure eat lots of it…
The average American consumes 55 pounds of wheat flour every year, making refined flour the #1 source of calories in the American Diet – a situation that nutrition expert Chris Kresser describes as, “a public health catastrophe.”
So, what is the truth about bread and wheat?
- Is it the perfect poison… or an essential daily food?
- Is “gluten-free” bread better for you than regular bread?
- And can you still eat bread… while maintaining a lean body and optimal health?
The answers to these questions may surprise you!
Be sure to read #5 – the biggest surprise of all!
Recently, Doctor of Naturopathy, weight-loss expert and best-selling Amazon author Liz Swann Miller, creator of the Red Smoothie Detox Factor, revealed 2 of the secrets to easy, steady weight loss. Secrets the big food corporations do their best to hide from us.
Secret #1: Enjoy real food. Don’t fall for the lie that you have to deprive yourself to lose weight.
Secret #2: stop eating out. You will automatically eat less without even noticing.
Then start detoxing your body with tasty, nourishing smoothies that are just as easy on your wallet as they are easy to make.
Because a single day of enjoying Liz’ smoothies demonstrated the radical power of her superfood-packed red smoothies to make me feel incredibly good.
Now prepare yourself for one of the biggest weight loss secrets there is. A secret that, when you use it properly, can transform your body and your health.
You probably know most of us eat too much processed food. What you may not know is that it’s full of toxic chemicals and substandard, dirt-cheap ingredients designed to make you eat more…and force you to gain weight.
Here’s how it works.
“That stuff is just a lot of calories your body can’t use,” Liz told me, “Some are poison. And all these foods are stripped of the anti-oxidants and anti-inflammatories that help your body detox. The result? Your body expends huge amounts of calories to eliminate some toxins—the rest, it stores in your fat to protect you. This is why most people are hungry all the time. They’re not getting energy they need.”
“So… what’s going on with me? Why am I losing weight but not going hungry?”
Liz paused, then dropped the bombshell.
Your body is designed to burn fat. You just have to let it.
“What? I thought we were designed to store fat?!?” We were Skyping and I was practically shouting. Then I heard Liz say…
What good is a fat reserve if you can’t burn it?
Liz continued: “You’re drinking smoothies packed with phytonutrients, anti-oxidants and anti-inflammatories that pull toxins out of you like a tractor beam. Allowing your body to burn those toxin-filled fat stores… and releasing tremendous amounts of stored energy.”
So that’s why I’m losing weight without going hungry.
Watch Liz’ free presentation. It’s packed with revolutionary weight loss information—information that works. Because it’s based on how nature.
Click the button only if you want to wear smaller clothes, breathe easier, move more freely and just plain feel better.
- Which calories help you lose weight…and which ones help you gain it…
- The “diet” foods…some of them vegetables…that lead to weight gain and diabetes…
- The “low-fat” foods that can dramatically increase your risk of cancer.
- And the superfoods that rescue your body from this assault by detoxing you…
Revitalizing your metabolism so you can Shed pounds as well as toxins, renew your body and reset your internal clock by up to 7 years.
Because until now, the Red Smoothie Detox Factor has been available only to Liz’ private clients. But now that she’s perfected it to work for almost everyone, almost every time, Liz is sharing it with rest of us so we can feel better and look better.
Get Red Smoothie Detox Factor before the price goes back up.
Because Liz offers a ridiculously good guarantee. You have 60 days to decide you love the Red Smoothie Detox Factor. If you don’t love it—for any reason, or even no reason at all —Liz will refund your money. 100%. No questions asked.
Sponsored Health Resources
In the years that I've been working on this website project I've come across some amazing resources by some very special people. I'd like to share them with you here.
NOTE: I update these links often so please check back to see what's new!
1) Everyone knows green smoothies are healthy right? Have you heard of a “red” smoothie? If not, check out this story…
2) Forget what you've read about 10-day lemonade cleanses, 7-day detoxes with green juices and Gwyneth's gruel. All you need to do, and this is perfect for Saturday or or anytime really, is a simple 1-day cleanse.
3) This “hidden survival muscle” in your body will boost your energy levels, immune system, sexual function, strength and athletic performance when unlocked.
4) I thought it was virtually impossible for a website to be able to tell me anything even a little bit insightful after only submitting my name and date of birth... I was wrong!
5) Turmeric is amazing. The problem is - It's hard to absorb!
6) Wonder why your stomach still sticks out even though you're hammering the core exercises every day? It's a common myth that bulging belly is due to weak abdominal muscles.
7) Even if you're the most active of athletes, you may still suffer from tight hip flexors due to the amount of time you spend each day planted to a chair.
Enjoy! Let me know how these work out for you. And if you run across anything I've missed please let me know.